COLL 1 Biological recognition-based assembly of peptide nanotubes on surfaces and their functionalizations
نویسندگان
چکیده
Non-specific adsorption of immunoactive compounds on biosensor surfaces is an important concern in biosensor development. In this study, minimization of nonspecific adsorption onto selfassembled monolayer (SAM) biosensor platforms was studied using electrochemical immunoassay techniques. To compare non-specific adsorption resistance, Au electrodes individually modified with decanethiol (DT), tetraethylene glycol thiol (EG4-SH) and 11mercapto-1-undecanol (11-MUD) monolayers were compared to two component mixed monolayers based on these compounds. The compositions of mixed SAMS were determined by Raman spectroscopy and reflection-adsorption infrared spectroscopy (RAIRS). The electrochemical immunoassay experiments showed that the tetraethylene glycol thiol was the most resistant to non-specific adsorption.
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